Unfolding of Titin Immunoglobulin Domains by Steered Molecular Dynamics Simulation
نویسندگان
چکیده
منابع مشابه
Unfolding of titin immunoglobulin domains by steered molecular dynamics simulation.
Titin, a 1-microm-long protein found in striated muscle myofibrils, possesses unique elastic and extensibility properties in its I-band region, which is largely composed of a PEVK region (70% proline, glutamic acid, valine, and lysine residue) and seven-strand beta-sandwich immunoglobulin-like (Ig) domains. The behavior of titin as a multistage entropic spring has been shown in atomic force mic...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1998
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(98)77556-3